Journal of Vaccines & Vaccination

Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W. Walnut Street, IB 130, Indianapolis, IN 46202, United States

Biography

Isabelle Brock is currently working as a Professor in the Department of Molecular genetics. Isabelle Brock research interests includes Microbiology. She is serving as an editorial member and reviewer of several international reputed journals. She has successfully completed her Administrative responsibilities. Isabelle Brock has authored of many research articles/books related to Microbiology.

 

Publications

• Case Report   
  Mast Cells and COVID-19: A Case Report Implicating a Role of Mast Cell Activation in the Prevention and Treatment of COVID-19
  Author(s): Isabelle Brock* and Anne Maitland
  
  Coronavirus disease (COVID-19) is a heterogeneous syndrome following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of the upper respiratory tract. ln adults, the clinical condition can range from asymptomatic cases to severe acute respiratory syndrome and multi-organ dysfunction. Those at risk of developing COVID-19 related hyper inflammatory syndrome likely had an ineffective, innate immune response to this novel pathogen. Mast cells are associated with the epithelium, contributing to tissue homeostasis and epithelial barrier defense. Equipped with an array of pathogen receptors, mast cells exhibit distinct cytokine profiles, dependent on the tissue and the triggered pathogen receptors. Following viral infections, mast cells produce pro-inflammatory chemical mediators, such as Interleukin-1 (IL-1) and IL-6, and these cytokines has been sh.. View more»
  

  DOI: 10.35248/2157-7560.21.s12.005

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