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Hong Wang
Department of Research and Development, Beijing Khasar Medical Technology Co. Ltd., Beijing, China
Publications
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Research Article
The Self-Renewal Procedures of Mesenchymal Stem Cells in the Blood
Author(s): Wuyi Kong*, Hong Wang, XiaoPing Zhu and XiuJuan Han
Objective: Although Mesenchymal Stem Cells (MSCs) are most commonly used in cell therapy and stem cell research, the mechanism and the locations of their self-renewal are still unknown. Methods: Mouse blood was collected, and examined under microscopy. The results were compared with the data of Human Umbilical Cord Blood (HUCB) collected 10 years ago. Results: We found that the self-renewal for the mesenchymal stem cells in mouse blood and HUCB needs at least 5 steps. First, specific tube-shaped stem cell niches release long segmented materials composed of sand-like particles and semitransparent granules. Second, the sand-like particles and semitransparent granules separate from the segmented materials. Third, each of the individual semitransparent granules releases groups of fusiform-shaped structure.. View more»