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Hirofumi Nakayama
Thinkcyte, K.K., 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
Publications
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Mini Review
Evolving ghost cytometry may take away labels for manufacturing of cell-based therapy products
Author(s): Keisuke Wagatsuma, Hiroko Nomaru, Hirofumi Nakayama and Sadao Ota*
Cell-based therapies, including stem cell therapies and regenerative medicine, offer transformative solutions for previously untreatable diseases. However, their manufacturing processes differ significantly from traditional drug production, requiring stringent Quality Control (QC) measures for the cells to ensure safety, efficacy and reproducibility. Fluorescence-based Flow Cytometry (FCM) is one of current QC methods, but rely on molecular markers that have potential impact on cell states and functionality, while also increasing costs. Moreover, there are cases that appropriate markers for accurately predicting cell function or differentiation are not available. Label-Free Ghost Cytometry (LF-GC) addresses these challenges by leveraging high-resolution and high-content morphological data and machine learning to classify and sort cells without fluorescent labels. LF-GC enables non-inv.. View more»