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Harshaminder Kaur Grewal
Seema Dental College and Hospital, Rishikesh, Uttarakhand, India
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Research
Evaluation of α-Smooth Muscle Actin (α-SMA) in Intraosseous Lesions of Jaw-An Immunohistochemical Study
Author(s): Poonam Goel*, Harshaminder Kaur Grewal and Vaibhav Gupta
Introduction: Fibroblasts associated with tumor stroma called as “peritumoral fibroblasts”, “cancer-associated fibroblasts” or “myofibroblasts” encompass heterogenous and multifunctional cell populations, manifesting various phenotypes. Myofibroblasts are known to play a pivotal role in normal growth and development, wound healing, organ fibrosis and cancers. The role of myofibroblasts in the remodeling of ECM in various intraosseous lesions may affect the nature and growth of these lesions by influencing matrix formation, cellular proliferation, cellular migration, angiogenesis, and extracellular proteolytic activity. Aim and Objective: The following study was undertaken to evaluate the expression of α- smooth muscle actin in intraosseous lesions of the jaw and to correlate their role with the pathoge.. View more»