Journal of Vascular Medicine & Surgery

Department of Pharmacology, Nantong University School of Pharmacy, Nantong, China

Publications

• Research Article   
  Arginine Vasopressin Promotes Transient Contractile Responses through Distinct Mechanisms in Rat Aorta and Mesenteric Resistant Arteries
  Author(s): Weizhong Zhu*, Aihua Yang, Yifeng Zhang, Yuhang Wang, Xiaojun Wang, Hairong Bao and Jun Ren
  
  Background: Neurohormone-regulated peripheral vascular resistance is considered one of the factors governing blood pressure. This study was designed to evaluate the effect of Arginine Vasopressin (AVP) on contraction of endothelium-intact or denuded rat aorta and mesenteric resistant arteries. Method: The wire myograph technique was used to assess the contractility of the vascular smooth muscles in response to a high-K+, phenylephrine, AVP and inhibitors, etc. The time-course of agonist-evoked contraction was then recorded. The endothelium of the mesenteric resistance arteries and abdominal aorta were denuded by physical abrasion, as evidenced by acetylcholine-induced vasodilation dysfunction. Results: The result revealed that: (1) AVP, but neither high K+ nor phenylephrine, evoke.. View more»
  

  DOI: 10.35248/2329-6925.24.S25.560

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