Journal of Membrane Science & Technology

Departamento de Bioquímica, Universidade Federal de Sao Paulo, SP 04044-020, Brazil

Biography

Associate Professor at the Department of Biochemistry at Federal University of São Paulo and was Coordinator of the Biological Sciences Course in Medical Modality (Biomedicine) at EPM/UNIFESP in the period 2008-2012. Coordinated the Structuring Faculty Nucleus of the Biomedicine Course at EPM/UNIFESP between 2011-2017. Has experience in Biochemistry, with emphasis on Protein Chemistry, Intermediate Metabolism and Cell Biology. The research area in which he works is mainly focused on the subject that studies the proteins of the plasma kallikrein-kinin system etc.

Publications

• Research Article   
  Camera-less Terahertz Imaging Investigation of the Interaction of Factor XII Protein with the Human Stratum Corneum
  Author(s): Zia Shariat-Madar, Aunik Rahman, Bozena Michniak-Kohn, Guacyara Da Motta and Anis Rahman*
  
  This paper reports the use of camera-less terahertz imaging technique to measure zymogen factor XII (FXII) conformational changes in solution and upon binding to stratum corneum in the absence of its known endogenous potentiating complex, high molecular weight kininogen (HK)-Prekallikrein (PK) in real-time. FXII is synthesized in the liver and secreted into the circulation to serve as a blood coagulation factor. FXII has diverse biological functions. First, it serves as an accessary molecule to extend the generation of thrombin-induced platelet adhesion to the initially formed platelet monolayer. Secondly, FXII provides a robust stimulus for Bradykinin (BK)-induced hyper-permeability by disrupting vascular barriers. Using in vitro assays, studies have shown that FXII activation can occur on negatively charged surfaces. This activation is accelerated in the presence of kallikrein or ac.. View more»
  

  Abstract PDF