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Gashaw Adane
Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
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Research Article
Vaccine Candidates, Immuno-Dominant Antigens and Potent Vaccine Adjuvants for Preventing Cutaneous Leishmaniasis: A Systematic Review
Author(s): Abiy Ayele Angelo*, Gashaw Adane, Yeshambel Belyhun, Bisrat Birke Teketelew, Dereje Mengesha Berta, Elias Chane, Negesse Cherie and Mesele Nigus
Cutaneous leishmaniasis (CL) is the most common clinical form of leishmaniasis that causes skin disease. Currently, there is no licensed prophylactic vaccine for CL, as the mechanisms of healing and memory T-cell responses that develop after infection with CL are far from fully understood. A review of the published articles identifying CL vaccine candidates, immuno-dominant antigens and potent vaccine adjuvants is needed to provide comprehensive information. Therefore, we aimed to review vaccine candidates, immuno-dominant antigens and potent vaccine adjuvants for preventing cutaneous leishmaniasis. First-generation vaccine candidates showed complete protection of the specified animal model. They induced strong T-cell mediated and antibody-mediated humoral immune responses (e.g. Curdlan dectin-1, Total Leishmania Antigen (TLA) and L. infantum heat shock.. View more»