Journal of Bacteriology & Parasitology

Department of Critical Care, School of Medicine, Iwate Medical University, Morioka, Japan

Biography

Gaku Takahashi has extended his valuable service for many years and has been a recipient of many award and grants. His international experience includes various programs, contributions and participation in different countries for diverse fields of study.  His research interests reflect in his wide range of publications in various national and international journals.

Publications

• Research Article   
  Study of High Mobility Group Box 1 Values in Septic Disseminated Intravascular Coagulation Treated by Polymyxin-B Immobilized Fiber-Direct Hemoperfusion
  Author(s): Gaku Takahashi*, Shigeatsu Endo and Yoshihiro Inoue
  
  Background: High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine that acts as a final -phase endotoxin mediator. HMGB1 also increases the expression of tissue factors in human peripheral blood monocytes, and induces DIC. We investigated HMGB1 values when polymyxin-B immobilized fiber-direct hemoperfusion (PMXDHP) was performed for the treatment of septic DIC patients with endotoxemia. Methods: Serum high mobility group box 1 (HMGB1) levels were examined in 16 patients with septic disseminated intravascular coagulation (DIC) undergoing polymyxin-B-immobilized fiber-direct hemoperfusion (PMXDHP), whose serum endotoxin levels were ≥ 1.1 pg/mL and who exhibited shock symptoms. Results: Average acute physiology and chronic health evaluation (APACHE II) score was 32.2, average sequential organ failure asse.. View more»
  

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