Department of Biology and Biotechnology, University of Pavia, Pavia, Italy
I am investigating the role of TRP channels and store-operated Ca2+ entry (Stim1 and Orai1) in endothelial progenitor cells (EPCs) from both peripheral and umbilical cord blood. We are also studying the remodeling of the Ca2+ toolkit in EPCs from human cancer (kidney and breast) patients. Ca2+ channels might be a feasible target for both regenerative medicine and anti-cancer strategies. We use Ca2+ imaging and patch-clamp, Western Blotting and immunofluorescence, qRT-PCR and gene silencing.
Commentary
Solitary Layer of Squamous Endothelial Cells
Author(s): Francesco Moccia*