Department of General and Pediatric Surgery, University of Tashkent Medical Academy, Tashkent,, Uzbekistan
Research Article
Diabetic Nephropathy as an Experimental Way to Model Chronic Renal Failure
Author(s): A.O. Okhunov, S.S. Atakov, U.K. Kasimov, A.R. Bobobekov, N.Sh. Khudaibergenova, Sh.A.Khamdamov, Sh.A. Bobokulova, K.Kh. Boboev and F.M. Abdurakhmanov*
Background: As is known, the modeling of chronic renal failure against the background of diabetic nephropathy is
associated with the need to maximally approximate the conditions for its reproduction to the clinical one. Based on
the foregoing, the priority in the reproduction of chronic renal failure should come from the modeling of diabetes
mellitus, in particular diabetic nephropathy.
Purpose: To develop an experimental model of chronic renal failure against the background of diabetic nephropathy.
Methods: Experimental studies were carried out on rabbits with the choice of the optimal method from 5 series of
experiments. The evaluation was carried out according to the abortive course of the process, the development of
hyperglycemic coma, the presence of angiodillation and the reproducibility of the mod.. View more»