Journal of Aquaculture Research & Development

Department of Aquatic Science, Nanchang University, Nanchang, China

Publications

• Research Article   
  Nitazoxanide Activating keap1a/Nrf2 Signaling Pathway is Regulated by Cul3 of Criataria plicata
  Author(s): Wuting Lu, Feixiang Su, Fanhua Yang, Jinhua An, Baoqing Hu, Shaoqing Jian, Gang Yang* and Chungen Wen*
  
  Cul3 regulates the ubiquitination and degradation of Nrf2 in Nrf2/keap1a pathway under normal conditions. In aquatic invertebrates, the related mechanism of activating oxidative stress in mussels was studied by stimulating Cristatra plicata with Nitazoxanide (NTZ). The full-length Cul3 gene of C. plicata, designated CpCul3 was cloned. The comparative sequence analysis of CpCul3 gene and its homologous genes showed that CpCul3 gene was highly similar to the homologous genes of other species in amino acid sequence. The amino acid sequence of CpCul3 is 78%-98% similar to that of other invertebrates. In the phylogenetic tree, CpCul3 gene is more closely related to the Cul3 gene in other bivalves. After NTZ stimulation, the expression level of CpCul3 mRNA increased in hepatopancrea.. View more»
  

  DOI: 10.35248/2155-9546.24.15.887

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