Journal of Dermatitis

Pharmaceutical Science, Roche Pharma Research and Early Development, Roche Innovatition Centre, Basel F. Hoffmann-La Roche Ltd., Switzerland

Publications

• Review Article   
  Update on Non-immediate Drug Allergy Reactions: State and New Aspects
  Author(s): Enrique Gomez* and Natalia Blanca-Lopez
  
  Purpose of the review: Among the Adverse Drug Reactions (ADR), around 10-15% are driven by an immunological mechanism and considered as allergic drug reactions. Within the Type IV of drug allergic reactions and in accordance with Gell and Coombs classification, the non-immediate drug hypersensitivity reactions (NI-DHR) relates to the most complex group of drug allergy, being cellular mediated responses and appearing from 1 hour to several weeks after drug/metabolites exposure. Current diagnosis protocols are limited and there is an unmet need to identify a diagnostic approach that mimic the pathological response and enhance the possibilities for a more accurate and realistic diagnosis. Recent findings: Changes in gene patterns induced during the acute phase of the NI-DHR provide clues of the underlying immunologica.. View more»
  

  DOI: 10.35248/2684-1436.21.6.133

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