Journal of Bioequivalence & Bioavailability

The Government Pharmaceutical Organization, 75/1 Rama VI Road, Ratchathewi, Bangkok 10400, Thailand

Publications

• Research Article   
  Assessment of Bioequivalence of Two Tramadol Hydrochloride 100 mg Extended-Release Tablet Formulations in Healthy Thai Volunteer
  Author(s): Vipada Khaowroongrueng*, Wiwat Supasena, Polsak Teerawonganan, Ekawan Yoosakul, Lalinthip Saeaue, Busarat Karachot, Isariya Techatanawat, Archawin Rojanawiwat and Praphassorn Surawattanawan
  
  Tramadol hydrochloride 100 mg extended-release tablets is available as the registered trademark, Tramal® retard in Thailand to reduce a dosing frequency for the treatment of moderate to severe pain. The Government Pharmaceutical Organization had developed the generic tramadol hydrochloride 100 mg extended-release tablets (Tramadol retard GPO®) to serve as an alternative product which is more accessible and affordable without compromising quality. Two separate single-dose bioequivalence studies under fasting and fed conditions and one multiple-dose bioequivalence study under fasting conditions were conducted in healthy Thai volunteers using a comparative randomized, two-way crossover, open-label design to demonstrate the equivalence in bio pharmaceutics quality between two tramadol formulations. Tramadol plasma concentrations were quan.. View more»
  

  DOI: 10.35248/0975-0851.22.14.468

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