Journal of Carcinogenesis & Mutagenesis

Centre for Astrobiology, University of Ruhuna, Matara, Sri Lanka

Biography

Dr. Edward J. Steele is an Australian molecular immunologist with interests in virology and evolution. He is an honorary research associate at the C.Y.O'Connor ERADE Village Foundation in Piara Waters, WA, Australia.  Dr. Edward J. Steele is the author/editors/reviewer in several international journals. He published 147 articles in many journals and the articles are informative and got good citations.

Publications

• Mini Review   
  Presumptive Evidence for ADAR1 A-to-I Deamination at WA-sites as the Mutagenic Genomic Driver in Hepatocellular and Related ADAR1-Hi Cancers
  Author(s): Robyn A. Lindley and Edward J. Steele*
  
  In hepatocellular cancer (HCC) there is an over expression of the RNA editing enzyme ADAR1. Further, the prominent genomic somatic mutation signature in HCC is almost exclusively focused on mutations at A:T base pairs where A-to-G mutations far exceed T-to-C mutations (when read on the non-transcribed strand). A clear mechanism for this extreme transcriptional strand biased mutation signature, putatively associated with over expression of ADAR1 deaminase, is yet to be explicitly demonstrated. The standard description of this strand bias has been nominally called “Transcription Coupled Damage” (TCD) to distinguish it from more conventional “Transcription Coupled Repair” (TCR). We show that the TCD description does not satisfy all features of the molecular evidence. The conventional view is that ADAR1 is thought to target adenosines at WA-sites for editing to ino.. View more»
  

  DOI: 10.35248/2157-2518.20.S14.002

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