Journal of Clinical and Medical Sciences

Kathryn W. Davis Center for Regenerative Biology and Aging, Mount Desert Island Biological Laboratory, Maine, United States of America

Publications

• Review Article   
  Stress-Induced Eukaryotic Translational Regulatory Mechanisms
  Author(s): Dilawar Ahmad Mir*, Zhengxin Ma, Jordan Horrocks and Aric Rogers
  
  The eukaryotic protein synthesis process entails intricate stages governed by diverse mechanisms to tightly regulate translation. Translational regulation during stress is pivotal for maintaining cellular homeostasis, ensuring the accurate expression of essential proteins is important for survival. This selective translational control mechanism is integral to cellular adaptation and resilience under adverse conditions. This review manuscript explores various mechanisms involved in selective translational regulation, focusing on mRNA-specific and global regulatory processes. Key aspects of translational control include translation initiation, which is often a rate-limiting step, and involves the formation of the eIF4F complex and recruitment of mRNA to ribosomes. Regulation of translation initiation factors, such as eIF4E, eIF4E2, and eIF2, through phosphorylation and intera.. View more»
  

  DOI: 10.35248/2593-9947.24.8.277

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