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Dianchen Hua
Department of Thoracic Cardiovascular Surgery, The Second Clinical Medical School of Inner Mongolia University for the Nationalities, Yakeshi, China
Publications
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Research Article
TGF-Beta Signaling Pathways in the Study of Expression in Patients with Atrial Fibrillation Atrial Tissue
Author(s): Zhiliang Huang*, Yu Gao and Dianchen Hua
Objective: To explore the relationship between TGF-beta signaling pathway and atrial fibrillation in patients with mitral valve disease, and reveal the mechanism of TGF-beta signaling pathway in development of atrial fibrillation. Methods: Firstly, the fibrosis extent of right atrial appendage tissues were tested by Masson’s trichrome staining. Secondly, the protein expression of TGF-beta1, TGF-beta RI, RII, RIII, P-Smad2/3, Smad2/3, Smad4, Smad7, TAK1, p38, ATF-2 were tested by Western blot. Results: There were significant difference between atrial fibrillation group and control group in fibrosis extent and the diameter of left atria (p0.05). The patients with atrial fibrillation are associated with the more serious fibrosis and larger diameter of left atria. For further study, the Western bolt results revea.. View more»