Journal of Blood Disorders & Transfusion

Thrombosis and Vascular Diseases Laboratory, School of Health and Biomedical Sciences, STEM College, RMIT University, Bundoora, Victoria, Australia

Publications

• Research Article   
  Cryodepleted Plasma Exchange Improves Survival in Thrombotic Thrombocytopenic Purpura: A Systematic Review and Meta-Analysis
  Author(s): Andrea O. Sugay, Daniel Kerage and Denise E. Jackson*
  
  Objectives: Thrombotic Thrombocytopenic Purpura (TTP) is a rare disease Associated with a Deficiency in a Disintegrin-like Metalloproteinase with Thrombospondin Motif Type 1 Member 13 (ADAMTS13) leading to Unregulated Ultra-Large von Willebrand Factor (ULVWF), which forms platelet-rich thrombi in the microvasculature. The first-line treatment for TTP is Therapeutic Plasma Exchange (TPE) with Fresh Frozen Plasma (FFP) or Cryodepleted Plasma (CDP). CDP has been hypothesised to perform better because it contains minimal levels of ULVWF. This study aimed to explore whether CDP, rather than FFP, improves outcomes in patients with TTP. Methods: A systematic review and meta-analysis were performed according to the Preferred Reporting Item for Systematic Review and Meta-Analysis (PRISMA) guidelines. A comprehensive search and screening.. View more»
  

  DOI: 10.4172/2155-9864.24.15.604

  Abstract HTML PDF