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Denise E. Jackson
RMIT’s Laboratory Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia
Publications
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Research Article
Extended RBC Phenotype Matching Reduces the Incidence of Alloimmunization in Patients with Warm Autoimmune Haemolytic Anaemia (wAIHA)
Author(s): Chih-Chien Shao and Denise E. Jackson*
Background: Warm Autoimmune Haemolytic Anaemia (wAIHA) involves autoantibodies destroying red blood cells, often necessitating transfusions. Alloimmunization, the formation of antibodies against non-self-Red Blood Cells (RBC) antigens, complicates future transfusions. This review evaluates whether extended RBC phenotype matching reduces alloimmunization compared to standard ABO and Rh matching. Methods: Databases (PubMed, Scopus, Cochrane Library and Google Scholar) were searched for studies (2014- 2024) on wAIHA patients comparing basic, partial and full extended RBC phenotype matching. Eligible data were analysed using a random-effects model to assess alloimmunization risk reduction. Manual searches were performed using relevant references. Results: Ten studies, both retrospective and prospective, were .. View more»