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Denise E. Jackson
Department of Laboratory Medicine, RMIT University, Bundoora, Victoria, Australia
Publications
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Research Article
Incidence of CD36 Antibody Induced Alloimmunisation and CD36 Deficiency Distribution among Different Populations: A Systematic Review and Meta-Analysis
Author(s): Yutian Wang and Denise E. Jackson*
Alloimmunisation, such as Platelet Transfusion Refractoriness (PTR), is an immune response to foreign compounds upon host exposure to foreign antigens. Alloimmunisation can cause life-threatening effects in patients. Recent studies have reported alloimmunisation from CD36 deficiency, and the risk of alloimmunisation produced by anti- CD36 antibodies. This study aimed to determine the risk of anti-CD36 antibody-induced alloimmunisation in global populations. This systematic review used the Embase, PubMed, Scopus, and Web of Science as databases to search for relevant articles from 1995 to 2023. The meta-analysis used OpenMeta Analyst software to perform the one-arm analysis with binary random effect and maximum likelihood methods using arcsine transformed proportion. Alloimmunisation caused by CD36 antibody, with an overall rate of 0.83% (P-value<0.001; I2.. View more»