Journal of Blood Disorders & Transfusion

Department of Laboratory Medicine, RMIT University, Bundoora, Victoria, Australia

Publications

• Research Article   
  Rate of Alloimmunisation to D, E, C Antigens in Rh-Negative Individuals Transfused with O RhD Positive Red Blood Cells in Emergency Situations: A Systematic Review and Meta-Analysis
  Author(s): Rayanna C. Nunes, Sue Quiring and Denise E. Jackson*
  
  The limited supply of the universal blood, O RhD negative, has led to the implementation of transfusion policies regarding the standard use of O RhD positive blood in adult male and women of non-childbearing age in emergency situations. However, there are concerns over associated Rh alloimmunization risks, as Rh antigens have the potential to cause Hemolytic Transfusion Reaction (HTR) and Hemolytic Disease of the Fetus and Newborn (HDFN). Therefore, we thought to determine the rate of anti-D, anti-E and anti-C antibodies formation when this policy is applied. PubMed, Embase and SCOPUS were searched from inception date to August 2023 for eligible alloimmunisation studies with anti-D, anti-C and/or anti-E specific data. Meta-analyses were performed using Open Meta-Analyst software. Twelve studies were included in the RhD alloimmunisation meta-analysis. The relative risk of RhD.. View more»
  

  DOI: 10.4172/2155-9864.24.15.577

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