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Denis de Melo Soares
Faculty of Pharmacy, Federal University of Bahia, Salvador, Bahia, Brazil
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Review
Medicine Interchangeabilty in Brazil, is it Safe? A Systematic Review for the Last 15 Years about Oral Drugs
Author(s): Gabriel Silva Lima*, Gustavo Reis Sampaio and Denis de Melo Soares
Objectives: The goal of this study was to review studies about bioequivalence test (BE) for oral drugs interchangeability in Brazil. Methods: We searched two databases with a strict inclusion process: Conducted in Brazil; humans volunteers; cover the period from 2004 to 2019; be a comparative study between oral formulations; at least one Brazilian formulation under test and published in periodic; Two reviewers independently extracted the data. Results: 4628 articles screened; 68 articles were included. 67 applying clinical assays and 1 article Chow and Liu methodology. Across studies that evaluated BE by clinical assays 66 demonstrated BE comparing generic or similar to their reference medicine. Conclusion: These data can be used to inform interventions to change the public’s beliefs abou.. View more»