Advances in Pharmacoepidemiology and Drug Safety

Pharmaceutical Chemistry Unit, School of Pharmacy, Asmara College of Health Science, Asmara, Eritrea

Biography

Dawit Tesfai is currently working at the Pharmaceutical chemistry unit in the school of Pharmacy, which is located in Asmara city, Eritrea. His area of specialisation is in Pharmaceutical Chemistry, General medicine.

Publications

• Research   
  Challenges of Hepatotoxicity Associated with Isoniazid Preventive Therapy among People Living with HIV in Eritrea
  Author(s): Mulugeta Russom*, Araia Berhane, Merhawi Debesai, Hagos Andom, Dawit Tesfai, Zenawi Zeremariam, Selamawit Gebrehiwet, Nighisty Tesfamichael, Saleh Mohammed Said and Hagos Ahmed
  
  Background Isoniazid preventive therapy (IPT) is an intervention recommended by the WHO for prophylaxis of Tuberculosis (TB) in people living with HIV (PLWH) and reported as generally safe with little risk of hepatotoxicity. Following its introduction in Eritrea in 2014, IPT related hepatotoxicity and fatality have been frequently reported to the Eritrean Pharmacovigilance Centre. The aim of this study is, therefore, to quantify the risk of hepatotoxicity, evaluate the effectiveness of close laboratory monitoring, assess the causal relationship of IPT and hepatotoxicity, identify possible risk factors and assess preventability of Isoniazid-induced hepatotoxicity in PLWH. Methods This was an observational cohort study of PLWH on IPT enrolled from three Antiretroviral therapy (ART) Clinics in Asmara, Eritrea, between August.. View more»
  

  DOI: 10.35248/2167-1052.20.9.228

  Abstract HTML PDF