Journal of Data Mining in Genomics & Proteomics

Frontiers of Innovative Research in Science and Technology, Konan University, Kobe, 650-0047, Japan

Biography

Dr. Daisuke Miyoshi is an Associate professor in the Department of Biomolecular Engineering Research, Konan University, Japan. His study interests major on tissue engineering, biomaterials & biomimetic materials. Currently, Dr. Daisuke Miyoshi is the author/editors/reviewer in several international journals. He published 10 articles in many journals and the articles are informative and got good citations.

Publications

• Research Article   
  Novel Strategy of Photodynamic Therapy Targeting RAS mRNA with G-Quadruplex Ligands for Cancer Treatment
  Author(s): Takeru Torii, Wataru Sugimoto, Keiko Kawauchi* and Daisuke Miyoshi*
  
  The constitutive activation of RAS proteins is closely linked with the aggressiveness of cancer cells. Although RAS proteins are effective targets for cancer therapy, the development of drugs targeting RAS proteins has been unsuccessful so far due to the absence of a suitable active site for small molecule drugs. RAS mRNA that forms a Gquadruplex (G4) in the 5′-untranslated region (UTR) has been deemed as a druggable target. In this study, we demonstrated the advantages of photodynamic therapy (PDT) for the treatment of cancer using G4 ligands targeting RAS mRNA, including our previously reported ligand anionic phthalocyanine ZnAPC. .. View more»
  

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