Journal of Clinical and Medical Sciences

Laboratory of Clinical Nutrition, Naruto Research Institute, Otsuka Pharmaceutical, Kuguhara, Tateiw, Japan

Publications

• Editorial   
  Study of the Effects of Glucose Dosage in Parenteral Nutrition on Rat Thiamine Levels
  Author(s): Daisuke Harada*
  
  The objective of this study was to determine the relationship between glucose dosage in parenteral nutrition and reductions in levels of body thiamine in rats. Vitamin-free infusions with differing amounts of glucose were administered to normal or thiamine-deficient rats for 5 days, after which urinary thiamine excretion and the amounts of thiamine in the blood, liver, brain, and skeletal muscles were measured. The total energy dosage was set at three levels (98, 140, and 196 kcal/kg), and the dose of amino acids was constant among all groups. Urinary thiamine excretions on Day 5 decreased with increasing glucose dosage in the infusions. In normal rats, the amount of thiamine in the blood and all organs decreased compared with the diet group; however, no significant differences were found among the infusion groups. In thiamine-deficient rats, on the other hand, the amount of thiamine .. View more»
  

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