Department of Vascular Surgery, Pauls Stradins Clinical University, Hospital, 13 Pilsonu Street, Riga LV1002, Riga, Latvia
Research Article
Diagnosis and Treatment of Silent Coronary Ischemia May Reduce Adverse Cardiac Events and Improve Long-Term Survival of Patients Undergoing Lower-Extremity Revascularization
Author(s): Dainis Krievins*, Edgars Zellans, Gustavs Latkovskis and Christopher Zarins
Background: Patients with Peripheral Artery Disease (PAD) undergoing lower-extremity revascularization are at
increased risk of death and Myocardial Infarction (MI) due to co-existing Coronary Artery Disease (CAD) which is
often unrecognized due to absence of chest pain symptoms. A new cardiac diagnostic test, coronary CT-derived
Fractional Flow Reserve (FFRCT), can identify patients with unsuspected (silent) coronary ischemia. We sought to
determine whether pre-operative diagnosis of silent coronary ischemia using FFRCT can facilitate multidisciplinary
care to reduce post-operative death and MI and improve survival of PAD patients.
Methods: Symptomatic PAD patients with no cardiac history or symptoms were enrolled in a prospective, open-label
study of coronary CTA and FFRCT testing before lower.. View more»