Department of Oncology, Foundation for Cancer Research and Education, Earlysville, Virginia, USA
Research Article
Impact of Dutasteride on PSA Kinetics and Time to Progression in Men with PSA-only Recurrent Prostate Cancer
Author(s): Charles Myers*
Background: AVODART After Radical Therapy For Prostate Cancer Study (ARTS) reported dutasteride reduced
PSA Doubling (PSADT) at two years by 66% and disease progression by 59%. The durability of the cancer control is
unknown.
Objective: Explore the impact of dutasteride on PSADT and time to progression in men with PSA-only recurrent
disease. Design, Setting and Participants: Retrospective examination of the impact of dutasteride on PSA kinetics and
time to progression with PSA-only recurrent prostate cancer.
Intervention: Dutasteride daily.
Outcome, measurement and statistical analysis: Change in PSA over time was determined by linear regression of
natural log of PSA versus time. The slope of that curve was used as a measure of exponential PSA progression. Impact
of dutasteri.. View more»