Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Review Article
Submerged People with Chronic HCV Infection: An Important Global Health Problem in the Era of Direct-Acting Antiviral Agents
Author(s): Cristina Stasi*, Caterina Silvestri and Fabio Voller
Globally, the World Health Organization (WHO) estimated that 71 million people have chronic Hepatitis C Virus
(HCV) infection. A significant number of these will develop cirrhosis or liver cancer. Currently, new direct-acting
antiviral agents can cure more than 90% of HCV-infected patients. The new WHO strategy has introduced global
goals-against viral hepatitis, including a reduction of 30% of new cases of HCV and a 10% reduction in mortality by
2020. However, a considerable number of people in the developing world have very limited access to diagnoses and
treatment.
The HCV transmission has considerably changed, reflecting both the evolution of medicine and the health and
social changes. The HCV is usually spread through blood-to-blood contact. After the discovery of HCV in 1989,
antibody screening has drastically decreased the incidence of post-transfus.. View more»