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Behnaz Ashtari
Department of Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
Publications
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Research Article
Cellular Toxicity Mechanisms of TiCN-Cp-Ti Screw on Tooth Gum Cells in Rat
Author(s): Parvaneh Naserzadeh, Abbas Razmi, Ruhi Yesildal and Behnaz Ashtari*
Cellular toxicity mechanism of TiCN film deposited on Cp-Ti substrate by Cathodic Arc Physical Vapor Deposition (CAPVD) method has yet to be clarified. The present study is aimed at finding out the possible effects of synthesized TiCN on the isolated tooth gum cells and realizing its cytotoxicity mechanism under experimental conditions compared to that of Au screws (standard in medicine). Results of the XRD analysis showed that TiCN film was formed in coating. The SEM image of TiCN film displayed a rough and irregular morphology and fine-grained surface. In addition, some other features such as cell viability, the level of Reactive Oxygen Species (ROS), lipid peroxidation (MDA), Glutathione Count (GSH and GSSG), Adenosine Triphosphate (ATP) were examined. On the other hand, activity of succinate dehydrogenase (complex II), NADH dehydrogenase (complex I), Coenzyme .. View more»