Journal of Biomolecular Research & Therapeutics

Medical Laboratory Department, Faculty of Applied Medical Science, October 6 University, Egypt

Biography

Asaad A is working at Medical Laboratory Department, Faculty of Applied Medical Science, October 6 University, Egypt.He is a member of a number of organisations and has written numerous books and articles, including Diagnosis and Treatment of Rosacea, Demodykozu, Dermatitis Peryoralnoho Considering Factors Commonly Occurring Pathogenesis and Clinical Course Features Dermatoses.

Publications

• Original Research Article   
  Resveratrol Nanoemulsion: A Promising Protector Against Ethinylestradiol-Induced Hepatic Cholestasis in Female Rats
  Author(s): Hussein MA*, Kasser AK, Mohamed AT, Eraqy TH and Asaad A
  
  Ethinylestradiol (EE) induced cholestasis was reported in female rats-model. The present article aimed to investigate anticholestatic activity of Resveratrol Nanoemulsion (RENE) against EE-induced cholestasis in adult female rats. The mean particle size of RENE was 49.5 ± 0.05 nm and zeta potential of +15.75 with the observed shapes of nanoparticle was spherical. Also, the median lethal dose (LD50) of RENE in rats was 795 mg/kg body weight. Administration of 1/20 LD50 RENE (39.75 mg/kg.b.w.) to EE–treated rats normalize serum cholesterol level as well as against an increase of serum TBA, bilirubin concentration. The treatment also resulted in a significant increase in hepatic SOD and GPx. RENE inhibited serum ALP, ALT and γ-GT activities, as well as reduced serum TNF-α, NO, MMP-2 MMP-9 and hepatic MDA as compared to EE-treated rats. The r.. View more»
  

  DOI: 10.35248/2167-7956.19.8.175

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