Modern Chemistry & Applications

Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed to be University (BVDU), Pune 411038, India

Biography

Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed to be University (BVDU), Pune 411038, India. worked on pharmacokinetic and Pharmacodynamic Interaction of Andrographolide with Meloxicam in Wistar Rats

 

Publications

• Research Article   
  Pharmacokinetic and Pharmacodynamic Interaction of Andrographolide with Meloxicam in Wistar Rats
  Author(s): Mythili Srinivasan, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi and Kakasaheb Mahadik*
  
  Aim of the study: The primary aim of this study was to evaluate the possible pharmacokinetic and pharmacodynamics (anti-inflammatory) herb-drug interaction of Andrographolide (AN) with meloxicam (Melx) in Wistar rats. Materials and methods: A sensitive and validated RP-HPLC method was developed for the simultaneous estimation of AN and Melx in rat plasma. The oral administration of AN (60mg/kg), Melx 1.55mg/kg) and co-admin group in male-Wistar rats were given. The plasma drug concentration was evaluated using the RP-HPLC method and the pharmacokinetic parameters such as Cmax, Tmax, MRT, T½, CL, Vd, and AUC were calculated. Pharmacodynamic parameters such as Change in paw volume, mechanical hyperalgesia, and mechanical nociceptive threshold were evaluated for predicting the herb-drug interaction. Results:.. View more»
  

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