Department of Chemistry, Dr. H.S Gour University, Sagar, M.P, India
Review Article
Immune Response Towards COVID-19: A Review on Host Body
Author(s): Nimesh Singh*, Bharat Suthar, Abhay Mehta and Archna Pandey
As the world is witnessing the epidemic of COVID-19, a disease caused by a novel coronavirus, SARS-CoV-2,
emerging genetics and clinical evidences suggest a similar path to those of SARS and MERS. A cascade of viral
particles enters the body through the nose, eyes or mouth. Breathing carries some of these particles to the lower
respiratory tract where the spike proteins of the coronavirus, acting like a key, lock into epithelial cells that line the
respiratory tract as well as those in the the air sacs in the lungs. SARS-CoV-2 is able to stay undetected longer than
many flu or coronaviruses and its spike proteins are able to gain entry by unlocking the ACE2 protein on the lung
cells. Once in, they hijack the cell’s machinery, replicate and multiply and infect adjoining cells. Like the defining
ACE2 proteins on the epithelial cells, viruses too have a tell-ta.. View more»