Department of Clinical and Bioscience, University of Virginia, Virginia, USA
Review Article
Bringing Phage Biology Out-of-the Shadow and into the Bedside: When will Modern Medicine Use Thisally Virus in the Battle against Superbugs
Author(s): Andrea P. Borns* and Fella Ahriz
According to the World Health Organization (WHO), Antimicrobial Resistance (AMR) is a global crisis and a
growing challenge that threatens a century of progress in medicine, with alarming levels of antibiotic resistance being
reported by countries of all income levels. The spread of AMR organisms results in common diseases becoming
untreatable and lifesaving medical procedures riskier to perform. Healthcare-Acquired Infections (HAIs) carry the
highest-burden compared to all other infectious diseases including HIV, tuberculosis and influenza. In the lasttwo
decades, HAIs in the U.S. increased by 36%, with nearly 2 million patients infected and about 90,000 deaths. With
four different categories of infections accounting to 75% of HAIs in the acute-care hospital setting: Surgical-Site
Infections (SSIs), CentralLineAssociated Bloodstream Infections (CLABSIs), Ventilat.. View more»