Pharmaceutica Analytica Acta

St. Peters Institute of Pharmaceutical Sciences, Hanamkonda, Warangal, Telangana, India

Biography

Ampati Rahul works in the Department of Pharmaceutical Sciences, Hanamkonda, Warangal, Telangana, India.  The respected author has specialization in the field of Pharmaceutical Sciences .

Publications

• Research Article   
  Solubility Enhancement of Ritonavir: Co-Crystallization
  Author(s): Narala Sagar*, Ampati Rahul and Nanam Rajani
  
  The main objective of this work is to explore co-crystallization approach for increasing solubility of an antiretroviral drug, Ritonavir (RTN). In this study, different co-formers with different functional groups like carboxylic acid andacid amidewere tried in ratio of 1:1, 1:2 and 1:3 (RTN:Co-former) using neat grinding method. Co-formers used were citric acid (CIT) and adipic acid (ADP). The co-crystals formed were characterized by melting point determination, Fourier-transform infrared (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and solubility studies. Co-crystals of drug with CIT and ADP showed the improved dissolution profile when compared to the pure RTN. Melting point, DSC, FTIR spectra of co-crystals were different than pure drug and co-formers indicating their interaction. XRD patterns of co-crystals were not completely amorphous but less intense .. View more»
  

  DOI: 10.35248/2153-2435.20.11.621

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