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Amjad Ali Shah
Genome Editing & Sequencing Lab, National Centre for Bioinformatics, Quaid-i-Azam University Islamabad, Pakistan
Publications
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Review Article
Nanotechnology-based Doxorubicin delivery for the treatment of skin cancer: A comprehensive review
Author(s): Muhammad Farhat Ullah*, Amjad Ali Shah, Rashna Mirza, Yousaf Khan and Ariba Sattar
Skin cancer is becoming more prevalent, with a rapid increase in incidence, posing a substantial public health problem. Doxorubicin, an anticancer agent, recognized as one of the most potent medications, is frequently employed in the treatment of skin cancer. Nevertheless, its application is constrained by challenges such as restricted penetration, dose-dependent toxicity, the development of multidrug resistance, and its limited specificity for cancer cells. The utilization of nanoparticles (NPs) emerges as a promising strategy to effectively address the myriad challenges encountered in the skin cancer treatment of doxorubicin (DOX). The inherent characteristics and components of NPs provide a range of advantageous properties, including enhanced permeation, sustained release, biocompatibility, low immunogenicity, and reduced toxicity. Notably, the specificity and selectivity of NPs fo.. View more»