Journal of Nanomedicine & Nanotechnology

Department of Genetics, Faculty of Agriculture, Fayoum University, Egypt

Publications

• Research   
  Genotoxicity Assessment of Zinc Oxide Nanoparticles in Male Rats After Oral Administration Using Micronuclei and Comet Assay
  Author(s): Gamal Hassan Mohamedin*, Amal Ramadan G, Eissa G and Ahmed Yassein AM
  
  In the food and fertilizer industries, zinc oxide nanoparticles (ZnO-NPs) are frequently utilized. In our investigation, rats received oral administration of ZnO NPs with a particle size of 30 ±5 nm once daily at doses of 100, 200, 300, 400, and 500 mg/kg for ten weeks in order to assess the genotoxic effect. Impacts on hematological markers, genotoxic impact, and growth were investigated. The results indicated that ZnO-NPs significantly reduced body weight gain, red blood cell count (RBC), hemoglobin concentration (Hb), hematocrit value (HCT), and platelet count (PLT), while increasing white blood cell (WBC), mean capsular volume (MCV), mean capsular hemoglobin (MCH), and mean capsular hemoglobin concentration (MCHC) in the treated rats. Our data show a dosage-dependent increase in DNA fragmentation for both the comet assay and the micronuclei test, which was supported by an i.. View more»
  

  DOI: 10.35248/2157-7439.22.13.631

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