Journal of Data Mining in Genomics & Proteomics

Structural Bioinformatics Group, Research Programme on Biomedical Informatics, Department of Experimental and Health Science, Universitat Pompeu Fabra, Barcelona 08003, Catalonia, Spain

Biography

Dr. Alberto Meseguer is an Associate professor in the Department of Experimental and Health Sciences, University Pompeu Fabra, Spain. His study interests major on Chronic non-communicable diseases, Eye disease. Currently, Dr. Alberto Meseguer is the author/editors/reviewer in several international journals. He published 10 articles in many journals and the articles are informative and got good citations.

Publications

• Commentary   
  Short Commentary on: On the Prediction of DNA-binding Preferences of C2H2-ZF Domains Using Structural Models: Application on Human CTCF
  Author(s): Alberto Meseguer, Ruben Molina-Fernández, Narcis Fernandez-Fuentes, Oriol Fornes* and Baldo Oliva*
  
  In the work entitled “On the prediction of DNA-binding preferences of C2H2-ZF domains using structural models: application on human CTCF” we present a new computational method to predict the DNA-binding preferences for Cis2-His2 zinc finger (C2H2-ZF) protein-domains from their amino acid sequence or structure. The method uses the structures of protein-DNA complexes to calculate a set of knowledge-based statistical potentials. Given the low numbers of protein-DNA complexes with known structure, we supplement the set of structures with experimental yeast-one-hybrid interactions of more than 170000 sequence-designed C2H2-ZF domains. We have implemented a server to model the structure of any protein-DNA complex of this family and derive its theoretical Position Weight Matrix based on the best scores of interactions calculated with the statistical potential.. View more»
  

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