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Akhouri A Sinha
Department of Genetics and Cell Biology, University of Minnesota, Minneapolis, USA
Publications
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Research Article
Antiestrogen Treatment for Androgen-Insensitive or Castration-Resistant Prostate Cancer, Identification of Estrogen Stem Cells, and Estrogen Receptors
Author(s): Akhouri A Sinha*
Objective: A variety of treatments (such as bilateral castration, chemical castration, adrenalectomy and hypophysectomy) have not cured adenocarcinoma of Prostate Cancer (PC). We hypothesize that sub type (s) can exist resulting in the failures of the above treatments.After Androgen Deprivation Therapy (ADT), PC emerges as androgen-insensitive or Castration-Resistant Prostate Cancer (CRPC).Our study is designed to identify a sub type of PC. Materials and Methods: DES (diethylstilbestrol) treated and untreated prostate biopsy specimens were utilized to identify two sub-types, androgen-sensitive and androgen-insensitive, tumours. Additional studies, such as localization of isotopic estrogen and estrogen antibodies, were designed to further define the sub types of PC. Results: Localization of isotopic es.. View more»