Journal of Nanomedicine & Nanotechnology

A.R. College of Pharmacy & G.H Patel Institute of Pharmacy, Charotar University of Science and Technology, Gujarat, India

Publications

• Research Article   
  Formulation Development & Characterization of Nintedanib loaded Micellar Drug Delivery System for improved therapy of Idiopathic Pulmonary Fibrosis
  Author(s): Rajesh Palva*, Ahmedraza R. Memon, Rajnikant Suthar and Musaratafrin Saiyed
  
  Aim: The study aims to create a formulation of Nintedanib Esylate loaded Polymeric Micelles for treating Idiopathic pulmonary fibrosis (IPF) by administering the drug via the pulmonary route, preventing adverse side effects from oral administration. Experimental work: The study aimed to optimize polymeric micelles preparation using various polymers and drugs. The optimal polymer ratio was selected using a Central composite design, and the impact of polymer concentration on drug entry efficiency was evaluated. The optimized batch was used for drug release and Dry Powder Inhaler (DPI) preparation. Result and Discussion: Solvent emulsification yielded polymeric micelles with high encapsulation efficiency (%EE) increasing with polymer concentration. Particle size (10-100 nm) was confirmed. Central composite design optimized Solutol-HS 15 (400 mg): Soluplus (300 mg) ratio for maximum %EE (.. View more»
  

  DOI: 10.35248/2157-7439.24.15.738

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