Department of Endocrinology, University of Alfaisal, Riyadh, Saudi Arabia
Research Article
Association between SGLT2 Inhibitors and Diabetic Ketoacidosis among Patients Fasting in Ramadan
Author(s): Salem Alsuwaidan*, Abdullah M Al Ruqaib, Abdulrahman A Al Ghamdi, Abdulaziz Al Jamaan, Majd M Abdulmowla and Fahad F Al Deaji
Aims: The use of SGLT2 inhibitors during Ramadan may be unsafe (risk of ketoacidosis, postural hypotension and
dehydration), specifically during long hours of Ramadan fasting in hot climates. The objective of this study was to
determine the main risk factors associated with the increased occurrence of DKA during Ramadan among patients
utilizing SGLT2 inhibitors and assess DKA risk during Ramadan.
Methods: This retrospective diagnostic study assessed the role of SGLT2 inhibitors in 99 patients (50 men and 49
women) with declared diabetes mellitus treated with empagliflozin and followed-up in diabetes clinics. The main
variables were:
1. Demographic data (age and gender).
2. Number of break days during Ramadan fasting.
3. Comorbidities associated with diabetes.
4. Signs and symptoms of DKA.
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