Journal of Microbial & Biochemical Technology

Abstract

Use the Best of MNPS-IHSP Nanoparticles with Coating of Ampicillin Antibiotic, as Bactericidal Properties

Mansour Binandeh*, Farokh Karimi and Sadegh Rostamnia

In this research, we have tried to maximize the potential of Fe₃O₄ magnetic nanoparticles coated by SiO₂ and immobilized with imidazoline hetropolymer (MNPS-IHSP) to stabilize and release the drug molecule called ampicillin (amp). In this purpose, nanoparticles of 50 nm in size were investigated under a tool such as; FT-IR, SEM, EDX detection and its structure in-vitro conditions. MNPS-IHSP nanoparticles is a specific and suitable nanocomposite that it have a mission as well as stabilizing the amp in the presence of silica coating (electrostatic bonding), that it called MNPS-IHSPA, and the results indicate a stabilization with a higher percentage of 85. It was beneficial to the silica coating. This measurement was performed by a UV-V is spectrophotometer analysis. Ultimately, in-vitro conditions, these magnetic nanoparticles that were migrating with ampicillin was tested on growing bacteria and resulted in the bacterial killing, indicating the antibacterial properties of magnetic nanoparticles. Ultimately, the project tells us that it can also be useful for destroying pathogenic bacteria living cells in vivo conditions.

Published Date: 2019-04-30; Received Date: 2019-03-07