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Abstract
Potentiation of Foot and Mouth Disease Vaccine by Irradiating Mid-Infrared Rays-A Laser Adjuvant Technology
Uma Kanthan T*, Madhu Mathi, Uma Devi and Siva Ramakrishnan
Vaccination is a safe method of disease prevention. Adjuvants that are used in vaccines enhance the immune response against vaccines at a certain level. The prevalence of using infrared in therapeutics is growing, and this necessitates the chance of employing it in vaccine technology to improve the vaccine potency and efficacy. In this study, we invented a 2-6 μm mid-Infrared (mid-IR) ray-generating atomizer, named MIRGA, and applied it to the Foot and Mouth Disease (FMD) vaccine only by externally spraying over the vial. The irradiation is found to have enhanced the titer of post-vaccination antibodies by several folds. Through various instrumentations, we demonstrated the photostimulation and photobiomodulation effects in the vaccine constituents caused by the applied mid-IR radiation. This technology is simple; it helps save money and resources, and it does not have any negative side effects. In the future, it could be an additional method or adjuvant for the potentiation vaccines.
Published Date: 2024-03-15; Received Date: 2024-02-13