Journal of Stem Cell Research & Therapy

Abstract

Percutaneous Application of Adipose Derived Stem Cells (ADSCs) in Non-Union of Long Bone Fractures

Himanshu Bansal*, Jerry Leon, Anupama Bansal and Iustin Preoteasa

Aim: Non-union is a common clinical complication that causes serious limb debilities and eventually leads to permanent limb impairment if not treated timely. Each bone fracture is unique and no common treatment modality will prove efficacious. To date, stem cells derived from bone marrow tissue are used for the treatment of non-union fractures. Present study reported personalized stem-cell therapy with Adipose tissue Derived Stem Cells (ADSCs)/ Stromal Vascular Fraction (SVF) in seven patients with history of non-union of long bones.

Methods: A total of 11 patients were enrolled for the study and 7 patients could be followed up for the treatment. ADSCs/SVF cells were extracted from adipose tissues and re-suspended in peripheral blood Plasma Rich in Platelets (PRP). The preparation was injected into the non-union site aided by fluoroscopic localization. The outcome was assessed using lower limb core scale and radiological screening. The patients were evaluated critically for any evidence of healing. If no evidence of healing was seen for any 6 month, the procedure was considered as failure.

Results and conclusion: We observed the long bone reunion in 6 of 7 (86%) patients in 4 months of SVF implantation. First evidence of healing was visible in five of the seven (71%) patients in 8 weeks post implantation of ADSCs suggesting the efficacy of the modality in treating atrophic non-union fractures. This is the first study that demonstrated the efficacy of ADSCs to treat non-union fractures. Present study is one of a trailblazer with more possibilities to resolve the practical difficulties of non-union fractures.

Published Date: 2024-09-13; Received Date: 2020-12-07