Pharmaceutica Analytica Acta

Abstract

Optimizing Ultrasound Parameters for Targeted Blood-Brain Barrier Disruption: A Computational Approach

Ryaan Datta*

The Blood-Brain Barrier (BBB) is a barrier between cranium and the neural tissues via blood, this barrier pose a significant challenge in treating brain diseases such as glioblastomas by restricting therapeutic agent delivery. This study explores the optimization of Focused Ultra Sound (FUS) settings to enhance BBB permeability, allowing localized delivery of treatments like Temozolomide (TMZ). Advanced simulation models, incorporating heterogeneity in vasculature and microbubble dynamics, were used to predict the optimal frequency, intensity and duration of FUS for safe and effective BBB disruption. The optimal settings 2.3333 MHz, 1.5 W/cm² and a duration of five minutes were identified, minimizing collateral damage while achieving precise BBB disruption. However, these findings, though encouraging, require further validation to confirm their clinical relevance for transcranial approaches. This study underscores the potential of computational models in guiding FUS parameter optimization, providing a foundation for non-invasive brain therapies.

Published Date: 2024-12-29; Received Date: 2024-10-29