Journal of Nanomedicine & Nanotechnology

Abstract

Mitochondria-Directed Glycated Oat Protein Nanoparticles for Improved Curcumin Delivery and Antioxidant Efficacy

Deog Jang*

This study investigates the application of mitochondria-directed glycated oat protein nanoparticles as a novel carrier system for enhancing the delivery and antioxidant efficacy of curcumin. Mitochondria-targeted drug delivery holds immense promise in mitigating cellular damage and restoring mitochondrial function, offering a strategic approach for the treatment of various diseases. Glycated oat protein nanoparticles, characterized by their biocompatibility and stability, serve as an efficient platform for curcumin encapsulation. Curcumin, a natural polyphenolic compound with potent antioxidant properties, faces challenges related to poor aqueous solubility and low bioavailability. Encapsulation within glycated oat protein nanoparticles enhances the stability, solubility, and mitochondria-targeted delivery of curcumin, thereby maximizing its therapeutic potential. This innovative approach holds significant promise for the management of diseases associated with mitochondrial dysfunction, including neurodegenerative disorders, cardiovascular diseases, metabolic disorders, and cancer. Further research is warranted to optimize nanoparticle formulation, evaluate safety profiles, and translate preclinical findings into clinical applications, ultimately advancing precision medicine in the field of nanomedicine.

Published Date: 2024-05-31; Received Date: 2024-05-01