Advances in Pharmacoepidemiology and Drug Safety

Abstract

Minimizing Stent Thrombosis with Drug-eluting Stent and Dual-Antiplatelet Therapy

Mehvish Sohail* and Muhammad Waqas Farooqi

Stent Thrombosis (ST) is a rare but serious complication of coronary stents. Untreated cases have higher mortality and recurrence rate. However, the use of Drug–Eluting Stent (DES) and Dual Antiplatelet Therapy (DAPT) have shown to give auspicious reduction in the complication rate. The mechanisms contributing to Stent thrombosis are multifactorial. Addressing the specific underlying pathology with customized optimization of particular stent and antiplatelet usage can bring substantial reduction in ST after stent implantation. Furthermore, advances in preventive imaging modalities have proven to timely identify any unforeseen event of ST allowing early intervention. Additionally, novel medical therapies have been tested, taking into account genotypic factors and individualized risk assessment for both ischemic and bleeding events.

Published Date: 2023-11-01; Received Date: 2023-10-02