Journal of Vaccines & Vaccination

Rajagopal Appavu

Biography

Dr. Rajagopal Appavu is Professor of pharmacology and Toxicology at the Sealy Center for Vaccine Development University of Texas Medical Branch-Galveston, Texas. He received his Ph.D. in Molecular Biophysics (Biochemistry) from Indian Institute of Science-Bangalore, India. He received his M.Sc. in Chemical Sciences from Pondicherry University, Puducherry and his B.Sc. in Chemistry from Govt. Arts College, Salem, Tamil Nadu. Dr. Rajagopal Appavu. research interests include • Broad curiosity in development of peptide/proteins as vaccine candidates, which includes protein-protein interaction analysis, synthesis of small molecules (organic/ inorganic/natural products), peptides (cyclic/acyclic disulfide bond formation), synthetic proteins via native chemical ligation approach, solution and solid-phase peptide synthesis and introduction of diverse chemical bonds in synthetic proteins • Structural determination of protein-DNA (Solid: X-ray, Solution: 2D & 3D NMR, and Gas: Mass Spectrometry) interactions and their pathways, stability, dynamics, and function • Molecular modeling and structure based drug design. Design, synthesis, and development of MRI contrast agents. • Molecular mechanism of intracellular traffic (endocytosis and exocytosis) incorporation ligand free-bound. Further, biophysics and biochemistry of nanoparticle peptide disease targets.

Research Interest

Broad curiosity in development of peptide/proteins as vaccine candidates, which includes protein-protein interaction analysis, synthesis of small molecules (organic/ inorganic/natural products), peptides (cyclic/acyclic disulfide bond formation), synthetic proteins via native chemical ligation approach, solution and solid-phase peptide synthesis and introduction of diverse chemical bonds in synthetic proteins • Structural determination of protein-DNA (Solid: X-ray, Solution: 2D & 3D NMR, and Gas: Mass Spectrometry) interactions and their pathways, stability, dynamics, and function • Molecular modeling and structure based drug design. Design, synthesis, and development of MRI contrast agents. • Molecular mechanism of intracellular traffic (endocytosis and exocytosis) incorporation ligand free-bound. Further, biophysics and biochemistry of nanoparticle peptide disease targets.