Journal of Liver

Wilson′s disease: Clinical presentations among patients attending gastroenterology clinic, Baghdad Teaching Hospital

3^rd World Congress on Hepatitis and Liver Diseases

October 10-12, 2016 Dubai, UAE

Akram Ajeel Najeeb

Medical City, Iraq

Posters & Accepted Abstracts: J Liver

Abstract:

Wilson�??s disease (WD) is an inherited disorder of copper metabolism that is characterized by tremendous variation in the clinical presentation. A descriptive cross sectional study with analytic elements was conducted during 2011, from the 1st of February till the 10th of June. The sampling method was a convenient non-random one, carried out through consecutive pooling of registered WD patients. A questionnaire-form paper had been developed for the process of data collection. The study had enrolled 29 patients with a male to female ratio of (1.07:1); their mean age was 27.12±12.18 years. 82.8% of them lived in urban area. 48.3% were singles. Only 20.7% of patients had a positive family history of WD. 69% of patients had consanguineous parents. The main initial clinical presentations were; hepato-neurologic (31%), pure hepatic (27.6%), neuropsychiatric (13.8%) and other presentations (27.6%). Hepatic manifestations were seen in 82.8% of patients; jaundice was the most frequent (89.7%). Ophthalmologic manifestations in 55.1% of patients show Kayser-Fleischer rings (51.7%), diplopia (6.9%) and cataracts (3.4%). Neurologic manifestations existed in 44.8% of patients; tremors were the most frequent (41.4%). Psychiatric manifestations existed in 31% of patients; depression was the commonest (27.6%). Joints manifestations existed in 20.7% of patients. The diagnosis delay was 11.26±8.2 months. In conclusion, the higher percentage of patients was of hepatoneurologic and pure hepatic presentations. Patients with hepato-neurologic type are diagnosed in older age, while those with neuro-psychiatric type are diagnosed in younger age and with longer diagnosis delay.

Biography :

Email: akram_git@yahoo.com