Journal of Vaccines & Vaccination

Vaginal vaccination with DNA loaded nano-particles

6^th Euro Global Summit and Expo on Vaccines & Vaccination

August 17-19, 2015 Birmingham, UK

Gulay Buyukkoroglu

Scientific Tracks Abstracts: J Vaccines Vaccin

Abstract:

Traditional vaccines are prepared of weakened or killed forms of bacteria or viruses and they usually require needle
injections by medical personnel. However, recently the focus is on DNA vaccines. It has been observed as a result of
studies carried out on experimental animals that these vaccines based on recombinant DNA technology which are obtained
with the help of gene engineering have provide cellular and humoral immune response. It is thought that DNA vaccines are
safer than vaccines made via killed viruses. These vaccines provide immunization by administering plasmids that carry the
DNA coding the antigen loaded nanoparticles directly to the target area such as muscle, skin or mucosa which results in the
production of antigen in the host cell. The female genital tract has been considered a component of the common mucosal
immune system. Antigen presenting cells (APCs), T cells and B cells populate cervix and vagina of the human and murine
female genital tract, indicating the potential for production of mucosal immunity at the genital tract by the local application of
plasmid DNA. Several studies have shown that direct application of DNA to the vaginal mucosal surface can induce secretion
of IgA molecules specific to the expressed protein. The topical application of DNA vaccine to the vagina is a useful method of
immunization because of its simplicity, painlessness and economy. That is why it is in question to administer DNA vaccines in
carrier systems as well as their targeting studies.

Biography :

Gulay Buyukkoroglu has completed PhD from Anadolu University and Postdoctoral studies from University of London, The School of Pharmacy on transcutaneous
DNA vaccination. She is head of Pharmaceutical Biotechnology at Anadolu University Faculty of Pharmacy. She is working on gene delivery systems, new cancer
drug delivery systems with siRNA and specific antibodies attached drug delivery systems.