Journal of Nanomedicine & Nanotechnology

Toxicity of iron oxide nanoparticles, on antioxidant enzymes and free radicals in male rats

26^th International Conference on ADVANCED NANOSCIENCE AND NANOTECHNOLOGY

December 05-06, 2022 | Dubai, UAE

Abdelsalam Abuzreda

University of Benghazi, Libya

Scientific Tracks Abstracts: J Nanomed Nanotechnol

Abstract:

The present study Wistar male rats were used. Rats were divided into 2 equal groups, 10 rats each. Group 1 served as control, group 2 was administered orally with Fe2O3NPs .Animals were treated with the doses every day for 90 days. Results showed significant (P < 0.05) decrease in the antioxidant enzymes (GPX, GST, CAT and SOD) and reduced glutathione (GSH) and total antioxidant capacity (TAC), while significant (P < 0.05) increase in thiobarbituric acid-reactive substances (TBARS) and nitric oxide (NO) in plasma and testes of rats treated with Fe2O3NPs, compared to control group. Keywords: Iron oxide nanoparticles; Antioxidant enzymes; Free radicals Recent Publications 1. Mosa IF, Abd HH, Abuzreda A, Yousif AB, Assaf N. (2021) Chitosan and curcumin nanoformulations against potential cardiac risks associated with hydroxyapatite nanoparticles in Wistar male rats. International Journal of Biomaterials. Jul 29;2021 2. Yousif AB, Mosa IF, Abd HH, Abuzreda A, Assaf N,.(2020) Bioevaluation of the role of chitosan and curcumin nanoparticles in ameliorating genotoxicity and inflammatory responses in rats’ gastric tissue followed hydroxyapatite nanoparticles’ oral uptake. Toxicology Research. Jul;9(4):493-508. 3. Yousef MI, Abuzreda AA, Kamel MA, (2019). Cardiotoxicity and lung toxicity in male rats induced by long-term exposure to iron oxide and silver nanoparticles. Experimental and therapeutic medicine. Dec 1;18(6):4329-39.

Biography :

Abdelsalam Abuzreda is a Ph.D. graduate in Nanotoxicity on Molecular and Physiological Characteristics and he is the assistant professor and Postdoctoral research fellow at Benghazi University. Currently, he is a researcher in the Department of Health Safety and Environmental (HSE), Arabian Gulf Oil Company (AGOCO). He has contributed to various conferences and many publications in his research interests such as Material Characterization, Nanoparticle Synthesis, Nanoparticle Preparation, Nanomaterials Synthesis, Nanomaterials, Nanoscience, Nanostructured Materials, Nanobiotechnology, Polymers, and Biomaterials.