Journal of Stem Cell Research & Therapy

Towards personalized healthcare engineering: A new paradigm in blood disorder treatment

7^th Annual Conference on Stem Cell and Regenerative Medicine

August 04-05, 2016 Manchester, UK

Athanasios Mantalaris

Imperial College London, UK

Posters & Accepted Abstracts: J Stem Cell Res Ther

Abstract:

Personalized medicine is a medical model that proposes the customization of healthcare with decisions and practices being tailored to the individual patient by use of patient-specific information (initially genetics information) and/or the application of patient-specific cell-based therapies. The BioBlood project aims to deliver personalized healthcare through a �??step change�?� in the clinical field of hemato-oncology. BioBlood represents an engineered bio-inspired integrated experimental/modeling platform for normal and abnormal hematopoiesis that receives disease & patient input (patient primary cells & patient/diseasespecific data) and will produce cellular (red blood cell product) and drug (optimal drug treatment) therapies as its output. Herein, we will present the experimental platform, which is a novel three-dimensional hollow fibre bioreactor capable of culturing normal and abnormal hematopoietic cells in the absence of exogenous growth factors by mimicking the structure and function of the bone marrow, alongside a population balance model (PBM) that is able to capture cellular heterogenity and in particular leukemia heterogenity. The PBM, which is able to extract patient and disease-specific information are linked to a pharmacokinetic/pharmacodynamic (PD/PD) model, which is the used to optimize chemotherapy treatment in a personalized manner.

Biography :

Email: a.mantalaris@imperial.ac.uk